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The study compared
the neurodevelopment of three groups of children as they matured from the
ages of 13.5 to 18 years.
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In this specific
protocol, individual brain scan changes were “pooled” to create a database
for each group. Computer software was
used to create colorful graphics which reflected shrinkage (atrophy) of the
cortical surface of the brain.
[Recall the Tootsie Roll lollipop candy coating = cortical surface].
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Group One: 12
children with Childhood Onset Schizophrenia -- all of these children
had histories of negative responses to at least two conventional (first generation)
antipsychotics
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Group Two: 12
age-matched, gender-matched non-psychiatric controls
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Group Three: 10 children with Psychosis Not Otherwise
Specified -- these children displayed
mood and/or behavioral problems but never met the DSM criteria for
schizophrenia; these children had also failed at least 2 trials of
first-generation drugs
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