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  |  | On April 11, 2005,
  the Food and Drug Administration issued a Public Health 
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  |  | Advisory to inform
  healthcare professionals about a 1.6 to 1.7x 
  higher risk of 
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  |  | mortality for
  elderly demented patients following exposure to the “2nd 
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  |  | generation”
  antipsychotic drugs.  This alert
  reflected the detection of higher 
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  |  | death rates – mostly
  cardiac or pulmonary – in the FDA’s “Randomized 
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  |  | Controlled Trial”
  database for olanzapine (Zyprexa), risperidone (Rispderdal), 
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  |  | and quetiapine
  (Seroquel). 
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  |  | 
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  |  | Two years later,
  this warning was revised and expanded because of further 
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  |  | research
  discoveries.   On June 16, 2008, the
  FDA alerted physicians that the 
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  |  | risk of premature
  death in elderly demented patients was elevated by both 
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  |  | the “new” and “old”
  (1st generation) antipsychotic drugs. 
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  |  | 
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