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On April 11, 2005,
the Food and Drug Administration issued a Public Health
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Advisory to inform
healthcare professionals about a 1.6 to 1.7x
higher risk of
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mortality for
elderly demented patients following exposure to the “2nd
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generation”
antipsychotic drugs. This alert
reflected the detection of higher
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death rates – mostly
cardiac or pulmonary – in the FDA’s “Randomized
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Controlled Trial”
database for olanzapine (Zyprexa), risperidone (Rispderdal),
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and quetiapine
(Seroquel).
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Two years later,
this warning was revised and expanded because of further
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research
discoveries. On June 16, 2008, the
FDA alerted physicians that the
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risk of premature
death in elderly demented patients was elevated by both
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the “new” and “old”
(1st generation) antipsychotic drugs.
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