Researchers around the world have been working to establish an accurate but non-invasive test for the diagnosis of Alzheimer’s disease.   Several biomarkers have been suggested for this purpose, including spinal fluid levels of specific proteins (tissue transglutaminase and tau) and blood levels of apoD.
	In several studies that have investigated antipsychotic drug effects, old and new medications have been found to provoke increased levels of biomarkers which are associated with Alzheimer’s disease.
	tTG = tissue tranglutaminase
	an enzyme which cross-links proteins, including components of tangles and plaques.  Some scientists have speculated that tTG is a cause of, or marker for, programmed cell death.
	tau = component of intracellular (neuronal) neurofibrillary tangles
	apoD = component of compact beta-amyloid plaques