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Study Design:
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The experiment
exposed 18 adult male macaques (4.5 to 5.3 years of age) to clinically
relevant, oral doses of haloperidol (Haldol), olanzapine (Zyprexa), or
placebo (sucrose pellets).
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Animals received
treatment for approximately 1.5 to 2 years.
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Medications were
administered once a day, in order to produce serum drug levels equivalent to
those which occur in human patients at clinically recommended doses.
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At the end of the
experiment, the animals were sacrificed.
The brains of the medicated animals were compared to the brains of the
drug-free controls.
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