Recall that one of the key features of Alzheimer’s disease and other diseases which cause dementia is the death and disintegration of brain cells.
	The purpose of this slide is to call attention to the existence of more than a dozen early experiments in lab animals which were performed between the late 1950s and 1975.  Common to all of these investigations of drug effects were the discoveries that brief (2 week) and extended (up to 1 year) exposures to the first-generation antipsychotics resulted in diffuse damage throughout the brain.
	Regrettably, textbooks of medicine and medical training programs have excluded this legacy.  For professionals and laypersons who are interested in this well concealed history, the publications of the Austrian neuropathologist, Dr. Kurt Jellinger, are invaluable.