Similar investigations have been performed in non-human animals.  In studies involving mice and rats, exposures to clinically relevant doses of antipsychotic drugs (olanzapine, risperidone, or clozapine) have resulted in higher protein levels of apoD in the cortical and subcortical regions of the brain.
	Key Point:
	To reiterate, the relevance of this finding pertains to the fact that apoD is a core component of the amyloid plaques which are found in Alzheimer’s disease.