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In a postmortem
investigation of psychiatric patients who had received treatment with various
kinds of antipsychotic drugs, researchers evaluated the levels of apoD in two
different regions of the brain.
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Brain Region Tootsie Pop Equivalent
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DLPFC = dorsolateral
prefrontal cortex candy coating
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caudate = region of
the subcortex tootsie roll center
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Study Design:
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The study compared
two groups of medicated subjects (20 diagnosed with schizophrenia, 8
diagnosed with bipolar disorder) and one group of mentally healthy
controls. 75-90% of the psychiatric
patients had received treatment with antipsychotic drugs, consisting of 1st
generation drugs or clozapine.
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When compared to
drug-naive controls, patients exposed to antipsychotics had apoD levels that
were two times higher in the cortical and subcortical zones of the brain.
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