If antipsychotic drugs are causally related to Alzheimer’s pathology, it would be important for medical doctors and researchers to discern which anatomic abnormalities they potentially induce.

It is in this context that a recent discovery in neuroscience is most pertinent.  Using electron microscopy to investigate the smallest components of brain cells, a team of investigators at the University of Pittsburgh (Desai et al, 2005)  identified apolipoprotein D as a core component within the beta-amyloid deposits (plaques) which distinguish Alzheimer’s disease.