Historically, pathologists have devised a variety of chemical methods for preserving and examining brain tissue.   Accompanying these changes have been several revisions in the classification schemes (thresholds) used to decide if a specimen demonstrates “probable” vs. “definite” signs of Alzheimer’s disease.
	In light of the complexity of these revisions, there is a compelling record in the  medical literature which suggests a positive association between antipsychotic drugs and the appearance of Alzheimer’s pathology within the human brain.