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The defining
features of Alzheimer’s disease include (but are not limited to):
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1)abnormal deposits inside neurons (composed of a protein
known as “tau”, these are sometimes referred to as neurofibrillary tangles]
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2)abnormal deposits outside neurons (composed of a protein
known a
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beta-amyloid, these deposits are
referred to as amyloid plaques)
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3) the disintegration and death of neurons
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This slide depicts
Alzheimer’s abnormalities as they would appear through the
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lens of a
microscope. The pink cells (top
center, lower right) are neurons. An
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amyloid plaque can
be seen in the lower left. Tau tangles
appear inside the
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large neuron (dark
blue). Disintegrating cell parts
(microtubules) appear in
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white.
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