In the novel, Murder on the Orient Express – Agatha Christie’s famous fictional detective, Hercule Poirot, must determine the identity of the person who has killed a fellow train passenger.  The case is never definitively solved because there are twelve different suspects for the murder, each of whom has strong motives for the crime.

Like the Murder on the Orient Express, physicians overlook drugs as a cause of dementia because they usually focus upon other risk factors [when there are multiple suspects, some or all of them go free].

In the Academy Award winning film, Michael Clayton, an attorney who represents a large chemical company becomes a whistle blower after he discovers that his client has knowingly concealed the deadly effects of a farm product.  In an act of corporate retaliation, the attorney is cleverly killed by hit men so that his death appears to be a suicide.

Like the murder in Michael Clayton, drug-induced dementia in psychiatry is a “perfect crime” [no one suspects the drugs as the cause of dementia, because cognitive and behavioral deficits are blamed on the patient’s “pre-existing” mental health condition].