Old and new antipsychotics all increase Alzheimer’s proteins…
•Protein changes in antipsychotic recipients,
•relative to drug-free controls:
•
•sourcebiomarkerchange
•Austria 2005(CSF) tTG↑ 200-400%
•Italy2005(CSF)tau↑ 24%
•USA2002(blood)apoD↑ 58%
•
•
•CSF = cerebrospinal fluid
•
•
Researchers around
the world have been working to establish an accurate but non-invasive test
for the diagnosis of Alzheimer’s disease.Several biomarkers have been suggested for this purpose, including
spinal fluid levels of specific proteins (tissue transglutaminase and tau)
and blood levels of apoD.
In several
studies that have investigated antipsychotic drug effects, old and new
medications have been found to provoke increased levels of biomarkers which
are associated with Alzheimer’s disease.
tTG = tissue
tranglutaminase
an enzyme which
cross-links proteins, including components of tangles and plaques.Some scientists have speculated that tTG is
a cause of, or marker for, programmed cell death.
tau = component of
intracellular (neuronal) neurofibrillary tangles