The experiment
exposed 18 adult male macaques (4.5 to 5.3 years of age) to clinically
relevant, oral doses of haloperidol (Haldol), olanzapine (Zyprexa), or
placebo (sucrose pellets).
Animals received
treatment for approximately 1.5 to 2 years.
Medications were
administered once a day, in order to produce serum drug levels equivalent to
those which occur in human patients at clinically recommended doses.
At the end of the
experiment, the animals were sacrificed.The brains of the medicated animals were compared to the brains of the
drug-free controls.