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The fact that the
first-generation drugs were diffusely neurotoxic was not regarded as a
problem when antipsychotics arrived on the market in the 1950s. Ironically, the destructive capacity of
these pharmaceuticals was initially celebrated as a necessary component of
drug therapy, because psychiatrists mistakenly believed that psychosis could
be cured via chemical lobotomy.
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Unfortunately,
many physicians who practice medicine today may not appreciate the continuing
evidence from animal experiments which has revealed the potential of old and
new drugs to destroy the brain.
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In this context, a
recent series of publications prepared by scientists at the University of
Pittsburgh have produced dramatic results.
Motivated by a desire to understand the cellular effects of lab
techniques (do the sequential steps involved in the preparation or storage of
brain tissue alter the tissue in any way), the investigators made several
vital discoveries.
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