•2002 Bozikas – 18 schizophrenia patients vs. 14
age-matched controls
• patients
had 400% á tangle density in cortex (layer II of
EC)
• patients had á
plaque density (throughout the brain)
•
•2005 Ballard et al – studied 40 patients with Lewy body
dementia
• 23 patients avoided antipsychotic drugs
• 17
patients received antipsychotics
• when
compared to the other patients, the 17 drug-consumers exhibited:
• 30% higher density of cortical plaques
• 65-367% higher density of tangles
•
•