Zyprexa: Balancing Serious Side Effects With Serious Illness
Lawyers for the state of Alaska have spent weeks arguing in an Anchorage courthouse that Eli Lilly hid the dangers of its antipsychotic drug Zyprexa — a claim Lilly denies.
In a state courtroom one floor down, a less remarked upon case earlier this month illuminated the complex questions patients and doctors have to wrestle with when deciding whether to use imperfect but often helpful antipsychotic drugs to treat profound mental illness.
A 55-year-old man named William Bigley, in court for a hearing to decide whether he should be sent against his will to a psychiatric hospital, told the judge that Zyprexa and similar antipsychotics were ‘poison’ and he did not need them, the New York Times reports. “I’m fine,” he said. He also said he knows President Bush, owns a private jet and has seen flying saucers.
Bigley has been diagnosed with paranoid schizophrenia, and he’s been in and out of treatment for more than 20 years. He’s taken Zyprexa, Risperdal, Haldol and Thorazine, among other antipsychotic drugs. But he hasn’t been known to be violent or suicidal.
In Alaska, a patient has to be violent, suicidal or a danger to himself to be hospitalized against his will. So the judge in Bigley’s case let him go, against the recommendations of doctors who believed his erratic behavior could easily get him into physical trouble with the police or others.
Meanwhile, the legal fight continues over whether Lilly concealed Zyprexa’s side effects — which can include weight gain and an increased risk of diabetes — to protect sales of the multi-billion-dollar drug.
This is all much ado about nothing. Lilly should have immunity from suit and should not even be questioned by outside scientists! This action is an outrage. The people at Lilly would never put a drug on the market that was not safe and effective. There should be a law against even questioning their positions on this wonderdrug.
Tort
Reform’s comments are right on target. If we can’t trust Eli Lilly,
next thing you know, people will start calling Vice President Dick
Cheney an evil person who has total disdain for the American people.
Quoting Dick Cheney’s response when ABC’s Martha Raddnitz asked him to
comment on a recent poll that 2/3 of Americans don’t like the way the
war in Iraq is going:
Cheney, after a five second pause, “So.”
I assume you’re being sarcastic.
I’m a psychologist and have seen wonders worked by Zyprexa. At the same time, there are serious side effects and diabetes risk is one of them. Diabetes is so much more dangerous for psychotic individuals who are already very disorganized and cannot manage their lives never mind a persistent day-to-day disease like diabetes. Hence, as with most drugs, there are risks and benefits that have to be balanced. In considering this issue, having THE FACTS about risks and benefits is the only way to talk intelligently.
Zyprexa qualifies for a MedGuide warning:
(1) The labeling would definitely help prevent serious adverse events;
(2) Few patients would be willing to take the drug and risk developing
diabetes given that numerous studies have shown Zyprexa to be no more
effective than the older class of antipsychotics that do not cause
diabetes; and
(3) Most patients on Zyprexa would learn that the drug is not FDA approved to treat the condition they have.
Zyprexa is considered by the Doctors in my clinic hometown Bangor Maine as the Worst offender of the atypicals.
Eli Lilly is in trouble for their off label “viva zyprexa” campaign of pushing the drug on people like me who had PTSD and got diabetes.
I never should have been on it in the first place all it did was give me side effects and make me sleep all day.
Sorry to hear about your bad health consequences from using Zyprexa. My comment above about Eli Lilly and Dick Cheney was a snide comparison not meant to be taken literally. In the cases of drugs like FenPhen, Vioxx, Baycol, Trovan and Zelnorm, to name five, the FDA let the drug companies release to the public wonder drugs that turned out to be hazardous to many patients’ health. The FDA decision to later pull these drugs off the market does not cure the damage these drugs have already done to some patients.
The sad truth is that, once a product is on the market and making lots of money, there is little financial incentive for pharmaceutical companies to perform extensive studies regarding side effects which did not show up with statistical significance during the clinical trial phase. Thus, Lilly was able to claim, based on its clinical trial data, that there was no link between Zyprexa and diabetes; this denial was even AFTER publication of studies in Japan which demonstrated a link. Research and Development does its best, but once products hit the Marketing arena, its all about protecting sales.
This is the reason why FDA is mandating long term safety studies after the drug approvals.
Pharma companies are not the evil that will continue to push the drugs
that are detrimental to the patients. Physicians and the patients
should make the decisions to take or continue a drug or not, if the
benefit from the drug outweighs the risk from the drug. This is neither
a rocket science nor voodoo.
We may want to think this before we push the blame on the pharma companies.
The bottom line that we all need to remember is: there is no drug with out side effects. Weigh the benefits and risks.
The main point is Lilly knew of the dangers but hide the true results. Also there marketing practice of use ot approved, has hurt many. How would you like to be give a drug mfor depressio and now be a diebtic
I am a engineer who has bipolar disorder. I have been not had a good response to my treatment for the first several years of my illness. As a result I suffered thru some real tough times w/ may family and work. My life started to improve once I started taking Zyprexa - I did gain weight ( over 25 pounds in the first 3 months) but I felt well and I was consider stable. There is no drug that is perfect but this one helped me.
http://news.google.com/news?hl=en&ned=us&ie=UTF-8&ncl=1145883559
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